Korean bioprinting startup develops 3D respiratory epithelium mannequin for virus analysis

CLECELL, a Korean 3D bioprinting startup, has developed a respiratory epithelium mannequin utilizing its proprietary 3D bioprinting know-how.

The respiratory epithelium is discovered lining a lot of the respiratory tract. A mannequin of the respiratory epithelium can probably turn into a testbed for varied viruses. CLECELL performed analysis on respiratory epithelium fashions utilizing its 3D bioprinter, the U-FAB, for a while. Having produced a mannequin earlier this yr, the corporate suggests it may be used within the analysis of SARS-Cov-2, the virus pressure that causes COVID-19. 

On April 10th, CLECELL acquired a proper letter of correspondence from Harvard Medical College neurosurgeon Choi-Fong Cho, who sought to realize info on the respiratory epithelium mannequin to assist perceive SARS-Cov-2 and support within the creation of a vaccine. 

CLECELL's bioprinting technology. Photo via CLECELL.CLECELL’s bioprinting know-how. Photograph by way of CLECELL.

CLECELL’s 3D bioprinting know-how

CLECELL is an organization targeted on the analysis and growth of synthetic tissue and synthetic pores and skin by way of its proprietary 3D bioprinting know-how. This consists of the U-Printer, a 15 multi-channel 3D bioprinting system that facilitates the development of 3D multilayered constructions with low, center, and excessive viscosity biomaterials. 

The system makes use of a microinjection methodology for low viscosity biomaterials, which may help to extend the precision of the excessive viscosity extrusion to greater than 10 occasions the unique fee. This helps to extend cell viability by stopping injection shock and allows the manufacturing of varied shapes and outputs. In response to CLECELL, its different bioprinting system, the U-FAB, shall be utilized in researching tissue engineering on the Boston Bioprinting Consortium of students from Boston’s universities and hospitals. The consortium consists of eight joint-research groups with members from Harvard Medical College and MIT analysis groups.

CLECELL has additionally been researching and creating varied reconstructed human pores and skin fashions utilizing its 3D bioprinting know-how. The corporate goals to create transplantable biomimetic human pores and skin that clearly distinguishes between the dermis and dermis of the pores and skin. CLECELL has developed varied “U-Pores and skin” fashions together with full-thickness, dermis, pigmented, and hair follicle pores and skin fashions. 

CLECELL joins firms like Philadelphia-headquartered Allevi within the bioprinting market which can be offering their very own 3D bioprinting know-how and tissue materials options. Allevi operates with a mission assertion to “make it simple to design and engineer 3D tissues.” It has developed numerous bioprinters, together with the lately launched triple-extrusion Allevi 3D bioprinter, the Allevi 6, the Allevi 2 and the Allevi 1, which was launched February 2018.

The corporate additionally launched a pores and skin bioink equipment final yr for use together with its 3D bioprinters to provide patches of pores and skin. 

FELIXprinters, a Netherlands-based desktop 3D printer producer, lately introduced its transfer into the bioprinting market with the business availability of its BIOprinter. It has been developed with key options which can be particularly designed for medical, scientific, and analysis purposes.

The FELIX BIOprinter. Photo via FELIXprinters.The FELIX BIOprinter. Photograph by way of FELIXprinters.

Various methodology for creating vaccines

Epithelial tissues line the outer surfaces of organs and blood vessels all through the physique, in addition to the inside surfaces of cavities in lots of inside organs. As such, the respiratory epithelium strains the respiratory tract, the place it serves to moisten and shield the airways. It additionally acts as a barrier to potential pathogens and overseas particles and secretes mucus to forestall an infection and tissue damage.

Utilizing its U-FAB 3D bioprinter, CLECELL has been creating and researching respiratory epithelium fashions to help in analysis for viruses like SARS-Cov-2, probably in its place methodology within the creation of vaccines. It’s because the corporate explains in a press launch, “SARS-Cov-2 is markedly much less infectious in the direction of animals, so this methodology is being thought of as a possible different methodology to the previous methodology of utilizing fertilized eggs to create vaccines.” A typical methodology for creating vaccines revolves round injecting a fertilized egg with the virus, incubating it, after which extracting, diluting, and refining it into an antigen. This methodology, nonetheless, is now thought of troublesome as SARS-Cov-2 is just not as infectious in the direction of animals. CLECELL posits that its respiratory epithelium mannequin for in vitro testing can probably serve in its place.

Professor Cho contacted made an pressing request to CLECELL for additional info on the respiratory epithelium mannequin that the corporate had 3D bioprinted. An skilled in neurovascular analysis and the event of recent medication, Professor Cho is presently main a analysis staff that’s in search of to search out strategies for making a respiratory epithelium mannequin via 3D bioprinting know-how. 

In response to CLECELL, the analysis staff has acknowledged that the corporate’s 3D bioprinted mannequin can be of nice help in understanding SARS-Cov-2. Professor Cho’s analysis staff can be seeking to analysis SARS-Cov-2’s impact on vascular construction, the virus’s an infection routes, and creating an in vitro testing platform that mimics human lung tissue by way of utilizing the bioprinted mannequin, in line with the corporate. 

The nominations for the 2020 3D Printing Business Awards at the moment are open. Who do you suppose ought to make the shortlists for this yr’s present? Have your say now. 

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Featured picture reveals CLECELL’s bioprinting know-how. Photograph by way of CLECELL.

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